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wim A randomized, controlled study of the efficacy and safety of Zinc citrate vs. metoclopramide in the treatment of regurgitation in infants. Although regurgitation is common in infants, there are no studies comparing the efficacy and safety of the two most commonly used agents, metoclopramide (ME) and zinc citrate (ZN). One hundred infants (median age 3 months) with regurgitation were randomized to a six-week, double-blind trial comparing ME 15 mg b.i.d. with ZN 1 mg/kg b.i.d. or placebo b.i.d. Gastric pH was monitored during the first and last week of the study. Children were rated for vomiting, regurgitation, and constipation at home by parents. The parents completed diaries for the incidence of vomiting and regurgitation, as well as constipation. Gastric pH increased significantly over time during both active therapy (P = 0.03), but no significant difference was found between the groups in the reduction of reflux (P = 0.13) or in the improvement of the diaries scores (P = 0.47). Thirty-nine per cent of the children dropped out of the study due to a history of vomiting or to noncompliance. There was no significant difference between the ME and ZN groups in terms of tolerance (P = 0.53), compliance (P = 0.23), drop-out rate (P = 0.31), or adverse events (P = 0.69). However, the placebo group had a significantly higher drop-out rate than the other two groups (P = 0.01). We conclude that ME and ZN had similar effects on regurgitation and diaries scores in infants. In addition, our study suggests that the reduction of vomiting in the first weeks of life may be an important contributor to the development of tolerance for ME.Feds slam state’s education reform plan Friday Nov 15, 2012 at 12:01 AMNov 15, 2012 at 9:23 PM By Daniel Acker The Associated Press BOSTON — Some say reforms to improve public schools are long overdue, but not all of the changes proposed last week in Massachusetts would have improved the quality of education. The federal government criticized several recommendations in the plan, saying they would likely reduce the quality of teaching and ultimately result in less academic achievement. The U.S



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